SICKLE CONFIRM MODIFIED HEMOGLOBIN SOLUBILITY TEST, (Sickle Cell Screen /Confirm) Modified Hemoglobin Solubility Test

Title:

Sickle confirm modified hemoglobin solubility test

Category:

Diagnostic

NCS:

Inventors: Tim R. Randolph

Summary:

The present invention provides a method for determining sickle-cell zygosity in a subject,
comprising: forming a first solution comprising a sample from the subject, a phosphate buffer,
a detergent, and a reducing agent; subjecting the first solution to centrifugation to form
a second solution and a supernatant; taking a color reading of the supernatant and of the
second solution; optionally filtering the second solution to form a filtrate and a precipitate,
and optionally measuring the amount of the precipitation and the absorbance of the filtrate or
taking a color reading of the filtrate.

Patent:

U.S. patent pending

Manager:

Stephanie Kimzey, MBA

Office of Technology Management
Fusz Hall, Suite 253
Phone: 314-977-7731
kimzeysl@slu.edu