Latest technologies from Saint Louis University

Treat Prostate Cancer with Less Invasive Methods and Fewer Adverse Effects

kimzeysl@slu.edu — Tue, 06 Dec 2022 11:49:08 GMT

Treat Prostate Cancer with Less Invasive Methods and Fewer Adverse Effectshttps://sites.google.com/slu.edu/intellectualproperty/2023/23-012

Treating Cryptosporidium Caused Infectious Diseases

kimzeysl@slu.edu — Thu, 15 Sep 2022 08:16:42 GMT

Treating Cryptosporidium Caused Infectious Diseaseshttps://sites.google.com/slu.edu/intellectualproperty/2023/23-006

Reducing the Mortality of Invasive Fungal Infections

kimzeysl@slu.edu — Tue, 09 Aug 2022 09:24:08 GMT

Reducing the Mortality of Invasive Fungal Infectionshttps://sites.google.com/slu.edu/intellectualproperty/2023/23-003

Studying Rare Liver Diseases

kimzeysl@slu.edu — Thu, 04 Aug 2022 08:22:58 GMT

Studying Rare Liver Diseaseshttps://sites.google.com/slu.edu/intellectualproperty/2023/23-001

Preventing Mycobacterium Tuberculosis

kimzeysl@slu.edu — Wed, 27 Jul 2022 13:05:02 GMT

Preventing Mycobacterium Tuberculosishttps://sites.google.com/slu.edu/intellectualproperty/2023/23-002

Mitigating Liver and Gut Injury Associated with Short Gut Syndrome

kimzeysl@slu.edu — Mon, 11 Jul 2022 11:25:42 GMT

Mitigating Liver and Gut Injury Associated with Short Gut Syndromehttps://sites.google.com/slu.edu/intellectualproperty/2022/22-030

Developing Treatments for Head and Neck Squamous Cell Carcinoma

kimzeysl@slu.edu — Tue, 21 Jun 2022 14:10:39 GMT

Developing Treatments for Head and Neck Squamous Cell Carcinomahttps://sites.google.com/slu.edu/intellectualproperty/2022/22-027

Treating Osteogenesis Imperfecta with Pulsed Low-Dose RANKL

kimzeysl@slu.edu — Fri, 10 Jun 2022 07:39:15 GMT

Treating Osteogenesis Imperfecta with Pulsed Low-Dose RANKLhttps://sites.google.com/slu.edu/intellectualproperty/2016/16-022

Treating Diet-Induced Antherosclerosis

kimzeysl@slu.edu — Fri, 10 Jun 2022 07:39:00 GMT

Treating Diet-Induced Antherosclerosishttps://sites.google.com/slu.edu/intellectualproperty/2018/18-019

Treating Bone Loss with Low Dose RANKL Therapy

kimzeysl@slu.edu — Fri, 10 Jun 2022 07:36:59 GMT

Treating Bone Loss with Low Dose RANKL Therapyhttps://sites.google.com/slu.edu/intellectualproperty/2014/14-011

Improving the Efficacy of Immunotherapy

kimzeysl@slu.edu — Fri, 29 Apr 2022 08:12:20 GMT

Improving the Efficacy of Immunotherapyhttps://sites.google.com/slu.edu/intellectualproperty/2022/22-026

Reduce Post-Operative Inflammation in Neurosurgery Patients

kimzeysl@slu.edu — Thu, 17 Mar 2022 07:08:02 GMT

Reduce Post-Operative Inflammation in Neurosurgery Patientshttps://sites.google.com/slu.edu/intellectualproperty/2022/22-017

Improving the Effectiveness of Drug Screening

kimzeysl@slu.edu — Thu, 17 Mar 2022 07:07:40 GMT

Improving the Effectiveness of Drug Screeninghttps://sites.google.com/slu.edu/intellectualproperty/2022/22-018

Fabricating Microbridge Structures with Submicrometer Resolution

kimzeysl@slu.edu — Tue, 08 Feb 2022 11:56:36 GMT

Fabricating Microbridge Structures with Submicrometer Resolutionhttps://sites.google.com/slu.edu/intellectualproperty/2022/22-015

Treating Malaria Using Novel Clinical Drug Candidates that Exhibit Oral Efficacy with Once Daily Dosing

kimzeysl@slu.edu — Mon, 24 Jan 2022 11:50:03 GMT

Treating Malaria Using Novel Clinical Drug Candidates that Exhibit Oral Efficacy with Once Daily Dosinghttps://sites.google.com/slu.edu/intellectualproperty/2017/17-036

Studying Lymphangiogensis-related Immunoresponse to Tumor Cells

kimzeysl@slu.edu — Mon, 24 Jan 2022 11:33:07 GMT

Studying Lymphangiogensis-related Immunoresponse to Tumor CellsCRSBP-1 null and heterozygous miceMade available through distribution agreement with The Jackson LaboratoryJackson Stock Number: 006221 Description or Nomenclature: B6.129S1-Xlkdl/J (B6.129S1-Lyve1)

Control the epigenetic pathway to increase seed size and potential yield in plants or crops

kimzeysl@slu.edu — Mon, 24 Jan 2022 11:16:56 GMT

Maximizing the Yield of Plants and CropsControlling the epigenetic pathway to increase crop yieldshttps://sites.google.com/slu.edu/intellectualproperty/2022/22-008

Increasing the Yield of Plants and Crops

kimzeysl@slu.edu — Mon, 24 Jan 2022 11:14:43 GMT

Increasing the Yield of Plants and CropsManipulating the plant signaling pathway to increase yieldshttps://sites.google.com/slu.edu/intellectualproperty/2022/22-009

Designing Components and Devices with Physical and Electrical Characteristics Not Attainable with Currently Available Materials

kimzeysl@slu.edu — Tue, 17 Aug 2021 12:52:26 GMT

Designing Components and Devices with Physical and Electrical Characteristics Not Attainable with Currently Available Materialshttps://sites.google.com/slu.edu/intellectualproperty/2021/21-014

Treating Neurodegenerative Disorders Linked to TDP-43 Pathology

kimzeysl@slu.edu — Tue, 17 Aug 2021 12:32:40 GMT

Treating Neurodegenerative Disorders Linked to TDP-43 Pathologyhttps://sites.google.com/slu.edu/intellectualproperty/2022/22-001

Generating Proteins for High-Throughput Drug Screening Using Customized Plasmids for Expressing Nuclear Receptor Proteins in E. Coli

kimzeysl@slu.edu — Wed, 23 Jun 2021 09:12:20 GMT

Generating Proteins for High-Throughput Drug Screening Using Customized Plasmids for Expressing Nuclear Receptor Proteins in E. Coli Customized Plasmids That Express Stable Ligand Binding Domains for TLX, ERRalpha, ERRbeta, ERRgamma, REVERBalpha, and REVERBbeta in E. Coli Cells https://sites.google.com/slu.edu/intellectualproperty/2019/19-012

Creating Exhibitions of Annotated Collections

kimzeysl@slu.edu — Wed, 23 Jun 2021 09:02:51 GMT

Creating Exhibitions of Annotated Collectionshttps://sites.google.com/slu.edu/intellectualproperty/2020/20-001

Creating and Describing Collections of Digital Resources

kimzeysl@slu.edu — Wed, 23 Jun 2021 09:00:58 GMT

Creating and Describing Collections of Digital Resourceshttps://sites.google.com/slu.edu/intellectualproperty/2020/20-002

Automating the Analysis of Chimerism Data

kimzeysl@slu.edu — Tue, 15 Jun 2021 12:39:45 GMT

Automating the Analysis of Chimerism Data

Preventing and Treating Infections Caused by Herpesviridae Using Mutant Herpes Simplex Virus

kimzeysl@slu.edu — Tue, 15 Jun 2021 12:26:51 GMT

Preventing and Treating Infections Caused by Herpesviridae Using Mutant Herpes Simplex Virus

kimzeysl@slu.edu — Tue, 15 Jun 2021 12:25:28 GMT

Preventing and Treating Infections Caused by Herpesviridae Using Mutant Herpes Simplex Virus

Studying Oncolytic Adenovirus Vectors Using a Cotton Rat Model

kimzeysl@slu.edu — Tue, 15 Jun 2021 12:16:06 GMT

Studying Oncolytic Adenovirus Vectors Using a Cotton Rat Model

Predicting Weather-Driven Phenomena with High Spatial and Temporal Resolution

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:23:57 GMT

Predicting Weather-Driven Phenomena with High Spatial and Temporal Resolution

Increasing the Accuracy of In Vivo Models for Oncolytic Adenovirus Vectors with a Syrian Hamster Model

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:22:15 GMT

Increasing the Accuracy of In Vivo Models for Oncolytic Adenovirus Vectors with a Syrian Hamster Model

Improving the Handling Characteristics of Dental Repair Compounds

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:20:55 GMT

Improving the Handling Characteristics of Dental Repair Compounds

Predicting Weather-Driven Phenomena with High Spatial and Temporal Resolution

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:19:02 GMT

Predicting Weather-Driven Phenomena with High Spatial and Temporal Resolution

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:17:46 GMT

Predicting Weather-Driven Phenomena with High Spatial and Temporal Resolution

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:17:10 GMT

Predicting Weather-Driven Phenomena with High Spatial and Temporal Resolution

Detecting DNA and RNA at Zeptomole Scale Sensitivities

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:16:18 GMT

Title: Biolayer interferometry measurement of biological targets Category: Diagnostic NCS: Inventors: Hans Peter Zassenhaus Summary: Disclosed are methods and compositions for the ultrasensitive detection of oligonucleotides,proteins, protein complexes, biomolecules, and infectious agents using a peroxidase drivendeposition of substrates onto interferometry capable biosensors, coupled to the specificrecognition of the target molecules. More specifically, methods are disclosed to specificallyimmobilize biological target molecules onto the surface of interferometry capable biosensorsand t...

Preventing and Treating Influenza

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:15:38 GMT

Title: Peptides for inducing heterosubtypic influenza T cell responses Category: Therapeutic NCS: Inventors: Hoft Summary: This invention provides compositions and methods for generation of an anti-influenza immuneresponse. In particular, conserved T cell epitopes within matrix protein and nucleoproteincomponents of influenza virus have been identified and further screened for those structuresthat will bind either or both of HLA I and II molecules. Methods for vaccinating subjects withformulations of such peptides for the treatment or prevention of influenza infection also aredescribed....

Detecting and Quantifying Specific Proteins in Biological and Environmental Samples

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:14:47 GMT

Detecting and Quantifying Specific Proteins in Biological and Environmental Samples

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:14:15 GMT

Detecting and Quantifying Specific Proteins in Biological and Environmental Samples

Developing Therapies for Various Diseases Such as Fibrosis, Dermal Scarring, Retinal Disease, Cancers, and Viral Infections

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:12:54 GMT

Developing Therapies for Various Diseases Such as Fibrosis, Dermal Scarring, Retinal Disease, Cancers, and Viral InfectionsReference related technology SLU Tech ID 11-034.

Testing for Inherited Metabolic Diseases

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:12:04 GMT

Testing for Inherited Metabolic Diseases

Treating Cornelia de Lange Syndrome

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:10:38 GMT

Title: Use of indomethacin-based drugs to treat Cornelia de Lange Syndrome Category: Therapeutic NCS: Inventors: Dorsett, Fay Summary: Cornelia de Lange Syndrome (CdLS) is a devastating genetic syndrome that occurs approximately once per 10,000 births and displays slow growth, physical deformities in limbs, heart and kidney, mental retardation, speech deficits and autism. It is rarely inherited, and is usually caused by sporadic dominant mutations. Cd LS displays many features commonly seen in isolation in sporadic birth defects, thus treatments developed for it may be beneficial for ...

Preventing Breakage of Electrodes Placed in the Brain to Treat Movement Disorders and Compulsive Disorders

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:09:53 GMT

Title: Burr Hole Electrode Clamp Category: Medical Device NCS: Inventors: Bucholz Summary: This invention describes interacting jaws for clamping an electrode in position in a burr hole in the skull of a patient and a protective cap to maintain a large radius for the electrode. This device secures the electrode to minimize movement and breakage. Patent: U.S. patent application 13/709,673 Manager: Stephanie Kimzey, MBA

Treating Diseases With Pathologies Promoted by Angiogensis

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:09:20 GMT

Treating Diseases With Pathologies Promoted by Angiogensis

Curing Hepatitis B Infections Using a Therapy that Suppresses HBV Replication

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:08:21 GMT

Curing Hepatitis B Infections Using a Therapy that Suppresses HBV Replication

Treating Type I Diabetes Using a Therapy That Targets C-peptide

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:06:22 GMT

Title: Systems and methods for determining a C-Peptide receptor, and methods of using Category: Research Tool NCS: Inventor: Gina L.C. Yosten Summary: A method is provided for locating a G-protein coupled receptor (GPCR) for a selected peptide. The method comprises the following steps: screening biological matter expected to be responsive to the selected peptide for GPCR expression; create list of expressed GPCRs on list in hierarchal order; test a highest order GPCR on list that has not yet been tested for responsiveness; repeat process until a responsive GPCR is found or no more G...

Integrating Off-Chip Processes into Microfluidic Devices

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:05:34 GMT

Title: Microfluidic devices and methods for fabricating microfluidic devices Category: Industrial application NCS: Inventors: Martin, Alagic, Johnson-Hoover Summary: The present disclosure relates to microfluidic devices and methods for fabricating microfluidic devices having encapsulated tubing and encapsulated electrodes. The applicability of these devices enables integrating several off-chip analytical methods into the microfluidic device. This includes droplet transfer, droplet desegmentation, microchip-based flow injection analysis, and microdialysis sampling. The analytic perf...

Preventing Bone Loss

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:05:11 GMT

Title: Suppression of bone loss by introducing FoxP3+ CD8 T-cells (TcREG) Category: Therapeutic NCS: Inventors: Rajeev Aurora, Zachary Buchwald, Jennifer Kiesel Summary: This invention relates generally to a method of regulating osteoclast function via a bi-directional regulatory loop between osteoclasts and FoxP3+ CD8 T-cells. This previously unknown crosstalk between the skeletal and immune systems can be exploited through cell-based therapeutics, biologics, small molecule agonists or other known methodologies to treat bone loss and other inflammation-based diseases. A cell-base...

Treating Malaria Using Aminohydantoin Compounds

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:04:01 GMT

Title: Aminohydantoin Compounds as Antimalarial Agents Therapeutic NCS: Inventors: Marvin J. Meyers, Ke Ding, Jing Xu Summary: This invention relates generally to novel compositions and methods for treating malaria. It discloses that aminohydantoin compounds are inhibitors of Plasmodium aspartic proteases, such as plasmepsin II, while having reduced activity for human aspartic proteases, such as BASE and CatD. These compounds work through the aspartic protease mechanism to kill Plasmodium parasites which cause malaria. This novel mechanism of actio...

Measuring HbF in Blood Inexpensively

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:02:32 GMT

Title: Method of Hemoglobin-F Determination Category: Diagnostic NCS: Inventor: Tim R. Randolph Summary: Sickle cell anemia is one of the most commonly inherited genetic diseases, annually affecting approximately 275,000 births worldwide. Established treatments involve infection prophylaxis, pain management, and blood transfusion with iron chelation. A more recent approach to treatment involves the drug hydroxyurea to increase expression of fetal hemoglobin (HbF) to reduce the frequency of vaso-occlusive events. However, patients exhibit a wide range of baseline HbF levels and respons...

Inexpensively Predicting Weather Threats With High Spatial and Temporal Resolution

kimzeysl@slu.edu — Mon, 14 Jun 2021 13:00:55 GMT

Inexpensively Predicting Weather Threats With High Spatial and Temporal Resolution

Preventing and Treating Herpes Infections

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:59:39 GMT

Preventing and Treating Herpes Infectionshttps://sites.google.com/slu.edu/intellectualproperty/2015/15-016

Preventing and Treating Herpes and Hepatitis Viral Infections

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:59:01 GMT

Preventing and Treating Herpes and Hepatitis Viral Infectionshttps://sites.google.com/slu.edu/intellectualproperty/2015/15-017

Promoting Nerve Repair Using Neural Tissue Engineering

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:57:26 GMT

Promoting Nerve Repair Using Neural Tissue Engineering

Integrating Three-Dimensional Cell Culture Scaffolds in Microfluidic Devices

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:55:05 GMT

Integrating Three-Dimensional Cell Culture Scaffolds in Microfluidic Devices

Minimizing the Duration and Toxicity of Treatments for Infections Caused by the Fungal Pathogen Cryptococcus neoformans

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:54:47 GMT

Minimizing the Duration and Toxicity of Treatments for Infections Caused by the Fungal Pathogen Cryptococcus neoformans

Treating Coagulation Disorders Without Bleeding Side Effects

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:54:11 GMT

Treating Coagulation Disorders Without Bleeding Side Effects

Producing Nanomaterials Using Mask-Free Methods

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:51:57 GMT

Producing Nanomaterials Using Mask-Free Methods

Providing Immunity Against Divergent Strains of Influenza

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:50:42 GMT

Providing Immunity Against Divergent Strains of Influenza

Minimizing the Cost and Time Requirements for Hematopoietic Stem Cell Therapy (HSCT)

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:49:48 GMT

Minimizing the Cost and Time Requirements for Hematopoietic Stem Cell Therapy (HSCT)

Minimizing Inflammation While Treating Fibrosis

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:48:46 GMT

Minimizing Inflammation While Treating Fibrosis

Creating More Effective Antibiotics to Treat Illnesses Caused by Antimicrobial-Resistant ESKAPE Pathogens

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:47:46 GMT

Creating More Effective Antibiotics to Treat Illnesses Caused by Antimicrobial-Resistant ESKAPE Pathogens

Simplifying the Production of Dinaphthothiophenes Compounds

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:47:11 GMT

Simplifying the Production of Dinaphthothiophenes Compounds

Treating Cancer and Viral Infections Using Extracellular Vesicles as an Off-the- Shelf Product

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:46:07 GMT

Treating Cancer and Viral Infections Using Extracellular Vesicles as an Off-the- Shelf Product

Halting and Reversing the Progression of Facioscapulohumeral Muscular Dystrophy (FSHD)

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:45:08 GMT

Halting and Reversing the Progression of Facioscapulohumeral Muscular Dystrophy (FSHD)

Improving the Consistency of Image-guided Head and Neck Radiotherapy Delivery Using an Auto-adaptable Head Rest

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:44:17 GMT

Improving the Consistency of Image-guided Head and Neck Radiotherapy Delivery Using an Auto-adaptable Head Rest

Generating State Atomic Oxygen Using Visible Light

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:43:30 GMT

Generating State Atomic Oxygen Using Visible Light

Developing a Functional Cure for Hepatitis B

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:42:27 GMT

Developing a Functional Cure for Hepatitis Bhttps://sites.google.com/slu.edu/intellectualproperty/2018/18-027

Enabling High Precision, Low Cost Deuterium-Based Universal Metabolomic Isotope Labeling

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:41:48 GMT

Enabling High Precision, Low Cost Deuterium-Based Universal Metabolomic Isotope Labeling

Developing New Types of Molecules for Fluorescent Microscopy

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:38:06 GMT

Developing New Types of Molecules for Fluorescent Microscopy

Detecting Exposure to Specific Pathogens and Agents

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:37:10 GMT

Detecting Exposure to Specific Pathogens and Agents

Improving Tumor Immunotherapy

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:36:20 GMT

Improving Tumor Immunotherapy

Delivering Medicines in a Controlled Manner Over an Extended Period of Time Using Degradable Hydrogels

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:35:36 GMT

Delivering Medicines in a Controlled Manner Over an Extended Period of Time Using Degradable Hydrogels

Using GCNF Ligands to Increase the Efficacy of Cancer Therapeutics

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:34:48 GMT

Using GCNF Ligands to Increase the Efficacy of Cancer Therapeutics

Using a Novel Mechanism to Treat MRSA Infections and Tuberculosis

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:33:52 GMT

Using a Novel Mechanism to Treat MRSA Infections and Tuberculosis

Treating Neurological Diseases, Autoimmune Disorders, and Muscular Disorders Using Rev-erb Modulators

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:32:48 GMT

Treating Neurological Diseases, Autoimmune Disorders, and Muscular Disorders Using Rev-erb Modulators

Improving Telepathology

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:32:27 GMT

Improving Telepathology

Treating and Preventing Neuropathic Pain Using Novel Non-Narcotic Analgesics

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:31:25 GMT

Treating and Preventing Neuropathic Pain Using Novel Non-Narcotic Analgesics

Improving the X-Ray Imaging of the Vasculature of Biological Systems

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:28:13 GMT

Improving the X-Ray Imaging of the Vasculature of Biological Systems

Treating Traumatic Brain Injuries

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:27:14 GMT

Treating Traumatic Brain Injuries

Treating Neuropathic Pain with Greater Selectivity

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:26:08 GMT

Treating Neuropathic Pain with Greater Selectivity

Treating Facioscapulohumeral Muscular Dystrophy (FSHD)

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:25:33 GMT

Title: Compounds for treating Facioscapulohumeral Muscular Dystrophy and method for discovering Category: Therapeutic and Research Tool NCS: Inventors: Francis M. Sverdrup, Stephen J. Tapscott Summary: Facioscapulohumeral Muscular Dystrophy (FSHD) is characterized by epigenetic changes resulting in the aberrant expression of the DUX4 gene in muscle. Suppression of DUX4 expression is considered a therapeutic target for FSHD. But the mechanisms responsible for DUX expression are poorly understood and few targets are known amenable for small molecule drugs. A method is disclosed for usi...

Preventing and Treating Herpesvirus Infections from Strains Resistant to Anti-Herpesvirus Drugs

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:24:51 GMT

Title: Inhibitors of HSV Nucleotidyl Transferases and Uses Therefor Category: Therapeutic NCS: Inventors: John E. Tavis and Lynda A. Morrison Summary: This invention discloses that inhibitors of nucleotidyl-transferase superfamily enzymes from multiple different chemical classes profoundly suppress replication of HSV-1 and HSV-2 with no measurable toxicity in a short-term cell culture assay. Inhibition by these primary screening hits may already be superior to currently approved drugs for herpes virus infection, such as acyclovir. The test data indicate that the compounds inhibit at l...

Treating Chronic Neuropathic Pain

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:24:07 GMT

Treating Chronic Neuropathic Pain

Delivering Bioactive Components for Medical Treatments

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:23:18 GMT

Delivering Bioactive Components for Medical Treatments

Treating Protein C Deficiency

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:22:06 GMT

Title: Recombinant Thrombin-Thrombomodulin Fusion Protein Category: Diagnostic - Therapeutic NCS: Inventors: Barranco-Medina, Di Cera, Pozzi Summary: This invention discloses a novel technology for the manufacture of biopharmaceuticals and specifically thrombin-thrombomodulin fusion proteins with unique ability to activate Protein C in vitro and in vivo. The fusion proteins were obtained by fusing wild-type or mutant thrombin with a fragment of a receptor protein to produce a specific, fast, and cost-effective Protein C activator. This technology could be utilized to 1) replace a...

Diagnosing and Treating Infertility

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:20:54 GMT

Diagnosing and Treating Infertility

Treating Breast Cancer Using a Novel Therapeutic Strategy

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:19:51 GMT

Treating Breast Cancer Using a Novel Therapeutic Strategy

Developing Therapies for Various Diseases Such as Fibrosis, Dermal Scarring, Retinal Disease, Cancers, and Viral Infections

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:18:33 GMT

Developing Therapies for Various Diseases Such as Fibrosis, Dermal Scarring, Retinal Disease, Cancers, and Viral Infections

Diagnosing Halogen Gas Exposure and Eosinophil-driven Diseases

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:17:27 GMT

Diagnosing Halogen Gas Exposure and Eosinophil-driven Diseases

Preventing and Treating Chagas Disease

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:16:48 GMT

Preventing and Treating Chagas Disease

Researching Cell-Substrate Relationships Using Biomaterial Platforms

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:15:35 GMT

Researching Cell-Substrate Relationships Using Biomaterial Platforms

Treating Cancers, Neurodegenerative Diseases, and Other Rare Conditions

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:14:47 GMT

Treating Cancers, Neurodegenerative Diseases, and Other Rare Conditions

Measuring GPER Agonism, Antagonism, and Inverse Agonism Using a High-Throughput Screening Assay

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:13:33 GMT

Measuring GPER Agonism, Antagonism, and Inverse Agonism Using a High-Throughput Screening Assay

Maintaining GALNS Enzyme Activity for Extended Periods

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:12:39 GMT

Maintaining GALNS Enzyme Activity for Extended Periods

Regenerating Tissue Using Aligned Nano-fibrous Scaffolds

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:11:27 GMT

Regenerating Tissue Using Aligned Nano-fibrous Scaffolds

Treating Atherosclerosis

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:10:18 GMT

Treating Atherosclerosis

Treating Short Gut Syndrome and Preventing Necrotizing Enterocolitis Using Synthesized FA-EGF

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:09:19 GMT

Treating Short Gut Syndrome and Preventing Necrotizing Enterocolitis Using Synthesized FA-EGF

Treating Muscle Atrophy in FSHD Patients

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:08:20 GMT

Treating Muscle Atrophy in FSHD Patients

Screening for Bacterial Drug Resistance Using Novel Fluorescent Indicators

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:06:23 GMT

Screening for Bacterial Drug Resistance Using Novel Fluorescent Indicators

Treating Muscle Dysfunction Using Selective ERRg Compounds

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:05:08 GMT

Treating Muscle Dysfunction Using Selective ERRg Compounds

Simplifying the Simultaneous Analysis of Multiple Samples Using Mass Spectrometry

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:04:13 GMT

Simplifying the Simultaneous Analysis of Multiple Samples Using Mass Spectrometry

Developing More Effective Treatments for Malaria

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:03:13 GMT

Developing More Effective Treatments for Malaria

Assessing Biofilm Infections

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:02:19 GMT

Assessing Biofilm Infections

Using Shelf-Safe, Easy to Synthesize Cell Dyes to Study the Properties of Organic and Inorganic Substances

kimzeysl@slu.edu — Mon, 14 Jun 2021 12:00:27 GMT

Using Shelf-Safe, Easy to Synthesize Cell Dyes to Study the Properties of Organic and Inorganic Substances

Treating Cancer with Photodynamic Therapy Using Novel Molecules that Induce Apoptosis

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:59:40 GMT

Treating Cancer with Photodynamic Therapy Using Novel Molecules that Induce Apoptosis

Improving Cognitive Function in Aging- Related Dementia

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:58:52 GMT

Improving Cognitive Function in Aging- Related Dementia

Developing Treatments for Diseases Associated With the CLIC1 Gene

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:56:41 GMT

Developing Treatments for Diseases Associated With the CLIC1 Gene

Using Photo-Deoxygenation Induced Apoptosis to Treat Cancer

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:55:41 GMT

Using Photo-Deoxygenation Induced Apoptosis to Treat Cancer

Identifying GPER Agonists with Superior Selectivity

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:54:36 GMT

Identifying GPER Agonists with Superior Selectivity

Creating an Antiviral for the Treatment of Zika Virus

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:52:35 GMT

Creating an Antiviral for the Treatment of Zika Virus

Treating Frontotemporal Dementia

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:51:11 GMT

Treating Frontotemporal Dementiahttps://sites.google.com/slu.edu/intellectualproperty/2019/19-027

Improving DNA Sequencing

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:49:41 GMT

Improving DNA Sequencing

Preventing Rift Valley Fever in Humans

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:47:29 GMT

Preventing Rift Valley Fever in Humans

Treating Diarrhea in Transplant Patients, AIDS Patients, and Children

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:46:29 GMT

Treating Diarrhea in Transplant Patients, AIDS Patients, and Children

Minimize the Problem of Drug Resistance of BRCA-deficient Tumors

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:44:06 GMT

Minimize the Problem of Drug Resistance of BRCA-deficient Tumors

Minimize the Risks Associated with Supraphysiologic Iron that is Added to Infant Formulas to Offset Poor Iron Absorption

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:40:15 GMT

Minimize the Risks Associated with Supraphysiologic Iron that is Added to Infant Formulas to Offset Poor Iron Absorption

Evaluating a Variety of Therapeutics for Liver Disease with Robust Internal Control

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:39:00 GMT

Evaluating a Variety of Therapeutics for Liver Disease with Robust Internal Control

Diagnosing and Preventing Leukemias That Affect Both Adults and Children

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:38:12 GMT

Diagnosing and Preventing Leukemias That Affect Both Adults and Children

Minimizing Compliance Problems with Type 1 Diabetes Treatment

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:35:49 GMT

Minimizing Compliance Problems with Type 1 Diabetes Treatment

Minimizing Errors When Treating Diabetes Mellitus with Severe Hyperglycemia or Ketoacidosis

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:33:50 GMT

Minimizing Errors When Treating Diabetes Mellitus with Severe Hyperglycemia or Ketoacidosis

Facilitating Research to Develop Treatments for HFE-associated Hereditary Hemochromatosis

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:32:49 GMT

Facilitating Research to Develop Treatments for HFE-associated Hereditary Hemochromatosis

Treating Neuropathic Pain Without the Use of Opioids

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:31:45 GMT

Treating Neuropathic Pain Without the Use of Opioidshttps://sites.google.com/slu.edu/intellectualproperty/2021/21-008

Authenticating Users in a Secure and Non-Intrusive Manner

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:29:25 GMT

Authenticating Users in a Secure and Non-Intrusive Manner

Treating Triple Negative Breast Cancer and Endocrine-Resistant Cancer

kimzeysl@slu.edu — Mon, 14 Jun 2021 11:28:03 GMT

Treating Triple Negative Breast Cancer and Endocrine-Resistant Cancer

PiZ Transgenic Mice

kimzeysl@slu.edu — Thu, 25 Oct 2012 09:54:11 GMT

Title: PiZ transgenic mouse Category: Research Tool NCS: Inventor: Jeffrey H. Teckman Summary: Alpha-1-antitrypsin (a1AT) deficiency is caused by homozygosity for the a1AT mutant Zgene and occurs in 1 in 2000 births. The Z mutation confers an abnormal conformation onthe protein, resulting in an accumulation within the endoplasmic reticulum of hepatocytesrather than appropriate secretion. The accumulation of the mutant protein is strikinglyheterogeneous within the liver. Homozygous ZZ children and adults have an increased risk ofchronic liver disease, which is thought to result from this ...

Adenovirus E1A fragments for use in anti-cancer therapies

kimzeysl@slu.edu — Tue, 28 Aug 2012 13:47:48 GMT

Title: Adenovirus E1A fragments for use in anti-cancer therapies Category: Therapeutic NCS: Inventors: Maurice Green, Paul M. Loewenstein Summary: Up-regulation of the HER2/neu proto-oncogene occurs in several types of human cancer,including breast, ovary and prostate. HER2 up-regulation in breast cancer is predictive ofaggressive disease with a poor prognosis. In addition, several studies have shown that elevatedHER2 levels decrease the susceptibility of cancer cells to chemotherapy drugs. Further,treatment with siRNAs that inhibit HER2 translation was found to promote growth arrest an...

INPUT DEVICE, Finger Mouse for use in Operating Rooms.

kimzeysl@slu.edu — Tue, 28 Aug 2012 13:47:44 GMT

Title: Input device, a finger mouse for use in operating rooms Category: Medical device NCS: Inventor: Richard D. Bucholz Summary: This invention describes an input device used for controlling medical equipment controlledby a mouse. It comprises an elastic finger cot having an interior portion sized and shaped forselectively retaining an individual’s finger, and includes a light-emitting diode and light sensormounted on the cot to monitor movement, a transmitter to communicate with the equipment,and a power supply. Patent: US and foreign patents pending Manager: Stephanie Kimzey, MBA Off...

A Mouse Model for Hemochromatosis with HFE Gene Point Mutation

kimzeysl@slu.edu — Tue, 28 Aug 2012 13:47:43 GMT

Title: Hemochromatosis mouse with HFE gene point mutation Category: Research Tool NCS: Inventors: William S. Sly, Shunji Tomatsu , Xiao Zhou Summary: A mouse model for hemochromatosis wherein the HFE gene has been disrupted Patent: None Manager: Stephanie Kimzey, MBA Office of Technology ManagementFusz Hall, Suite 253Phone: 314-977-7731kimzeysl@slu.edu

SICKLE CONFIRM MODIFIED HEMOGLOBIN SOLUBILITY TEST, (Sickle Cell Screen /Confirm) Modified Hemoglobin Solubility Test

kimzeysl@slu.edu — Tue, 28 Aug 2012 12:28:31 GMT

Title: Sickle confirm modified hemoglobin solubility test Category: Diagnostic NCS: Inventors: Tim R. Randolph Summary: The present invention provides a method for determining sickle-cell zygosity in a subject,comprising: forming a first solution comprising a sample from the subject, a phosphate buffer,a detergent, and a reducing agent; subjecting the first solution to centrifugation to forma second solution and a supernatant; taking a color reading of the supernatant and of thesecond solution; optionally filtering the second solution to form a filtrate and a precipitate,and optionally ...

Distractor - Self Opening Brain Retractor for use with Robotic Systems

kimzeysl@slu.edu — Tue, 28 Aug 2012 12:28:28 GMT

Title: Distractor Category: Medical device NCS: Inventors: Richard D. Bucholz Summary: This invention describes a surgical distractor for distracting tissue of a patient to accessstructure underlying the tissue of the patient. The distractor includes a tube having a distalend adapted for insertion in tissue, a proximal end opposite the distal end, an exterior surfaceadapted for contacting the tissue, and an interior surface opposite the exterior surface defininga hollow interior extending between the distal end and the proximal end for accessing structureunderlying the tissue when the d...

Screening tool for Antiviral Agents: Hamster Adenovirus Screening Tool

kimzeysl@slu.edu — Tue, 28 Aug 2012 12:28:26 GMT

Title: Screening tool for antiviral agents Category: Research Tool NCS: Inventors: Karoly Toth, William S. M. Wold Summary: A method is provided for screening anti-adenovirus agents. The method includes reducing theactivation of the immune system of a small mammal, administering a human adenovirus vectorto the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virusunits within the tumor cells and the organs of the small mammal. Specifically, the immunesystem of the small mammal is suppressed using cyclophosphamide. The small mammal maybe, but is not limited...

Natural Killer Cell Line Derived from Healthy Human Male Donor

kimzeysl@slu.edu — Wed, 22 Aug 2012 08:22:13 GMT

Title: Human Natural Killer Cell Line – NK 3.3 Category: Research Tool NCS: Inventor: Jacki Kornbluth Summary: Natural killer (NK) cells act as an important defense against malignancy through their abilityto inhibit tumor metastases and destroy solid tumors and hematopoietic tumors. In additionnatural killer cells have anti-microbial activity, giving them a role in combating infectiousdiseases caused by bacteria, fungi, yeast and protozoal parasites. NK cells also target andkill cells that are infected with various types of viruses including herpes, influenza, hepatitis,po...

Herpes Simplex Virus-Expressing Host Costimulation Molecules

kimzeysl@slu.edu — Tue, 17 Jul 2012 11:42:14 GMT

Title: Virus-expressing host costimulation molecules Category: Therapeutic NCS: Inventors: Lynda A. Morrison, Lydia G. Thebeau, Jane E. Schrimpf Summary: An antiviral vaccine that encodes costimulation molecules for increasing immune responseto the particular virus at issue is provided herein. In an illustrative embodiment, in micelacking both B7-1 and B7-2 (B7KO), the increased severity of HSV infection has confirmed theimportance of these molecules in generation of HSV-specific immunity. To test the concept thatB7-1 or B7-2 expression by replication-defective HSV could augment its im...

Diagnostic method for Biomarkers of Adverse Coronary Events

kimzeysl@slu.edu — Tue, 17 Jul 2012 11:42:12 GMT

Title: Diagnostic method for biomarkers of adverse coronary events Category: Diagnostic NCS: Inventors: David A. Ford Summary: The present invention provides diagnostic methods for characterizing an individual's risk fordeveloping or having an adverse coronary event. More particular, the present invention isgenerally directed to characterizing an individual's risk for developing or having an adversecoronary event by determining the presence of myeloperoxidase-derived chlorinated lipids inbody fluids and tissues. The invention is predicated upon the discovery that tissue plasmalogensare ...